EPILEPSY AND COGNITION LAB
PUBLICATIONS
Ferrero, J. J., Hassan, A. R., Yu, Z., Zhao, Z., Ma, L., Wu, C., ... & Gelinas, J. N. (2025). Closed-loop electrical stimulation to prevent focal epilepsy progression and long-term memory impairment. Nature Neuroscience, accepted.
Gelinas, J.N., & Khodagholy, D. (2025). Interictal network dysfunction and cognitive impairment in epilepsy. Nature Reviews Neuroscience. PDF
Teoh, J., Simko, J., Camp, C. R., Liu, C. J., Wang, W., Williams, D., ... & Frankel, W. N. (2025). Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy. Brain, awaf125. PDF
Wisniewski, D. J., Ma, L., Rauhala, O. J., Cea, C., Zhao, Z., Ranschaert, A., ... & Khodagholy, D. (2025). Spatial control of doping in conducting polymers enables complementary, conformable, implantable internal ion-gated organic electrochemical transistors. Nature Communications, 16(1), 517. PDF
de Curtis, M., Asukile, M., Battaglia, G., Sellin, A., Cavalheiro, E., Galovic, M., ... & Research & Innovation Task Force of the ILAE. (2025). Basic and preclinical epilepsy research Scientists' perception of clinical epileptology. Epilepsia, 66(1), 60-74. PDF
Ma, L., Sands, T., Khodagholy, D., & Gelinas, J. (2024, December). Time Domain-Based Oscillatory Feature Extraction for High Spatiotemporal Resolution Neurophysiologic Data. In 2024 IEEE International Electron Devices Meeting (IEDM) (pp. 1-4). IEEE. PDF
Jakešová, M., Kunovský, O., Gablech, I., Khodagholy, D., Gelinas, J., & Glowacki, E. D. (2024). Coupling of photovoltaics with neurostimulation electrodes–optical to electrolytic transduction. Journal of Neural Engineering. PDF
Zhao, Z., Yu, H., Wisniewski, D. J., Cea, C., Ma, L., Trautmann, E. M., ... & Khodagholy, D. (2024). Formation of Anisotropic Conducting Interlayer for High‐Resolution Epidermal Electromyography Using Mixed‐Conducting Particulate Composite. Advanced Science, 2308014. PDF
Ma, L., Wisniewski, D. J., Cea, C., Khodagholy, D., & Gelinas, J. N. (2024). High‐Density, Conformable Conducting Polymer‐Based Implantable Neural Probes for the Developing Brain. Advanced Healthcare Materials, 2304164. PDF
Rauhala OJ, Ma L, Wisniewski DJ, Shao S, Schumacher B, Lopez JF, Kaspers M, Zhao Z, Gelinas JN, Khodagholy D. E‐Suture: Mixed‐Conducting Suture for Medical Devices. Advanced Healthcare Materials. 2024 Jan 14:2302613. PDF
Sands, T. T., & Gelinas, J. N. (2024). Epilepsy and encephalopathy. Pediatric Neurology, 150, 24-31. PDF
Yu H, Kim W, Park DK, Phi JH, Lim BC, Chae JH, Kim SK, Kim JK, Provenzano FA, Khodagholy D, Gelinas JN* (2023) Interaction of interictal epileptiform activity with sleep spindles is associated with cognitive deficits and adverse surgical outcome in pediatric focal epilepsy. Epilepsia. 2023;00:1–14. PDF
Cea C, Zhao Z, Wisniewski DJ, Spyropoulos GD, Polyravas A, Gelinas JN*, Khodagholy D* (2023) Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics. Nature Materials. 2023 Jul 10:1-9. PDF
Bernard C, Frauscher B, Gelinas J and Timofeev I (2023) Sleep, oscillations, and epilepsy. Epilepsia. PDF
Dahal P, Rauhala O, Khodagholy D*, Gelinas JN* (2023) Hippocampal–cortical coupling differentiates long-termmemory processes. PNAS, Vol. 120, No. 7. PDF
Vitale F, Gelinas JN, Cabrera LY (2022) Neurotechnology: Bridging the dialogue between engineers, material scientists, clinicians, and ethicists. Iscience. Nov 18;25(11). PDF
Khodagholy D*, Ferrero JJ, Park J, Zhao Z, Gelinas JN* (2023) Large-scale, closed-loop interrogation of neural circuits underlying cognition. Trends in Neurosciences. Oct 26. PDF
Hassan AR, Zhao Z, Ferrero JJ, Cea C, Jastrzebska‐Perfect P, Myers J, Asman P, Ince NF, McKhann G, Viswanathan A, Sheth SA, Khodagholy D*, Gelinas JN* (2022) Translational organic neural interface devices at single neuron resolution. Advanced Science. Sep;9(27):2202306. PDF
Robinson JT*, Rommelfanger KS*, Anikeeva PO, Etienne A, French J, Gelinas J, Grover P, Picard R (2022) Building a culture of responsible neurotech: neuroethics as socio-technical challenges. Neuron. Jul 6;110(13):2057-62. PDF
Pouliopoulos AN, Murillo MF, Noel RL, Batts AJ, Ji R, Kwon N, Yu H, Tong CK, Gelinas JN, Araghy DK, Hussaini SA, Konofagou EE* (2022) Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation. Brain stimulation. Jul 1;15(4):927-41. PDF
Silverå Ejneby M, Jakešová M, Ferrero JJ, Migliaccio L, Sahalianov I, Zhao Z, Berggren M, Khodagholy D, Đerek V*, Gelinas JN*, Głowacki ED* (2022) Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor. Nature Biomedical Engineering. Jun;6(6):741-53. PDF
Yao DR, Yu H, Rauhala OJ, Cea C, Zhao Z, Gelinas JN, Khodagholy D* (2022) Anisotropic Ion Conducting Particulate Composites for Bioelectronics. Advanced Science. Mar;9(9):2104404. PDF
Domínguez S, Ma L, Yu H, Pouchelon G, Mayer C, Spyropoulos GD, Cea C, Buzsáki G, Fishell G, Khodagholy D*, Gelinas JN* (2021) A transient postnatal quiescent period precedes emergence of mature cortical dynamics. Elife. Jul 23;10:e69011. PDF
Zhao Z, Cea C, Gelinas JN, Khodagholy D* (2021) Responsive manipulation of neural circuit pathology by fully implantable, front-end multiplexed embedded neuroelectronics. PNAS, Vol. 118, No. 20. PDF
Shore AN, Colombo S, Tobin WF, Petri S, Cullen ER, Dominguez S, Bostick CD, Beaumont MA, Williams D, Khodagholy D, Yang M, Lutz CM, Peng Y, Gelinas JN, Goldstein DB, Boland MJ, Frankle WN, Weston MC (2020) Reduced GABAergic neuron excitability, altered synaptic connectivity, and seizures in a KCNT1 gain-of-function mouse model of childhood epilepsy. Cell reports. Oct 27;33(4). PDF
Jastrzebska-Perfect P, Chowdhury S, Spyropoulos G, Zhao Z, Cea C, Gelinas JN*, Khodagholy D* (2020) Translational neuroelectronics. Advanced Functional Materials, 1909165. PDF
Jastrzebska-Perfect P, Spyropoulos G, Cea C, Zhao Z, Rauhala O, Viswanathan A, Sheth SA, Gelinas JN*, Khodagholy D* (2020) Mixed-conducting particulate composites for soft electronics. Science Advances, eaaz676. PDF Video
Cea C, Spyropoulos G, Jastrzebska-Perfect P, Gelinas JN*, Khodagholy D (2020) Enhancement mode ion-based transistor – comprehensive interface for in vivo electrophysiology. Nature Materials. PDF Video
Spyropoulos G, Savarin J, Gomez E, Simon D, Berggren M, Gelinas JN, Stavrinidou E, Khodagholy D (2019) Transcranial electrical stimulation and recording of brain activity using freestanding plant-based conducting polymer hydrogel composites. Advanced Materials Technologies, 1900652. PDF
Rauhala O, Dominguez S, Spyropoulos G, Ferrero-Lopez J, Boyers T, Jastrzebska-Perfect P, Cea C, Zhao Z, Khodagholy D, Gelinas JN (2019) Chitosan-based, biocompatible, solution processible films for in vivo localization of neural interface devices. Advanced Materials Technologies, 1900663. PDF
Dahal P, Ghani N, Flinker A, Dugan P, Friedman D, Doyle W, Devinsky O, Khodagholy D, Gelinas JN (2019) Interictal epileptiform discharges shape large-scale intercortical communication, Brain, 0:awz269, https://doi.org/10.1093/brain/awz269 PDF
Spyropoulos G, Gelinas J, Khodagholy D (2019). Internal-ion gated organic electrochemical transistor: a building block for integrated bioelectronics. Science Advances, 5:eaau7378. PDF
Nguyen PV, Gelinas JN (2018) Noradrenergic gating of long-lasting synaptic potentiation in the hippocampus: from neurobiology to translational biomedicine. Journal of Neurogenetics, 32:171-182. PDF
Gelinas JN, Baillet S, Bertrand O, Galvan A, Kolling T, Lachauz JP, Lindenberger U, Ribary U, Sawa A, Uhlhaas P (2018) Late adolescence: critical transitions into adulthood; In: Emergent brain dynamics: prebirth to adolescence, edited by A. A. Benasich and U. Ribary. Strüngmann Forum Reports, vol. 25, J. Lupp, series editor. Cambridge, MA: MIT Press. PDF
Khodagholy D*, Gelinas JN*, Buzsaki G (2017) Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus. Science 358:369-372. PDF
Gelinas JN, Khodagholy D, Thesen T, Devinsky O, Buzsaki G (2016) Interictal epileptiform discharges induced hippocampal-cortical coupling in temporal lobe epilepsy. Nat Med 22: 641–648. PDF
Khodagholy D*, Gelinas JN*, Zhao Z*, Yeh M, Long M, Greenlee JD, Doyle W, Devinsky O, Buzsáki G (2016) Organic electronics for high-resolution electrocorticography of the human brain. Science Advances 09 Nov 2016: DOI: 10.1126/sciadv.1601027 PDF
Watson BO, Levenstein D, Greene JP, Gelinas JN, Buzsáki G (2016) Network homeostasis and state dynamics of neocortical sleep. Neuron, S0896-6273(16)30056-3. doi: 10.1016/j.neuron.2016.03.036. PDF
Krook-Magnusson E*, Gelinas JN*, Soltesz I, Buzsaki G (2015) Neuroelectronics and biooptics: closed-loop technologies in neurological disorders. JAMA Neurol 72:823-9. PDF
Khodagholy D, Gelinas JN, Thesen T, Doyle W, Devinsky O, Malliaras G, Buzsaki G (2015) NeuroGrid: recording action potentials from the surface of the brain. Nat Neurosci 18:310-5. PDF
Liao P*, Gelinas JN*, Sirrs S (2014) Phenotypic variability of Krabbe disease across the lifespan. Can J Neurol Sci 41:5-12. PDF
Gelinas JN, Fitzpatrick KP, Kim HC, Bjornson BH (2014) Cerebellar language mapping and cerebral language dominance in pediatric epilepsy surgery patients. Neuroimage: Clinical 6:296-306. PDF
Gelinas JN*, Liao P*, Lehman A, Stockler S, Sirrs S (2012). Krabbe disease – a potentially treatable white matter disorder. Neurology 79:e170-2. PDF
Gelinas JN, Battison A, Smith S, Connolly MC, Steinbok P (2011). Electrocorticography and seizure outcomes in children with lesional epilepsy. Childs Nerv Syst 27:381-90. 13. PDF
O’Dell TJ, Connor SA, Gelinas JN, Nguyen PV (2010). Viagra for your synapses: Enhancement of long-term potentiation by activation of beta-adrenergic receptors. Cell Signal 22: 728-36. PDF
Gelinas JN, Tenorio G, Lemon N, Abel T, Nguyen PV (2008). Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus. Learn Mem 15: 281-9. PDF
Gelinas JN, Banko JL, Peters MM, Klann E, Weeber EJ, Nguyen PV (2008). Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. Learn Mem 15: 403-11. PDF
Gelinas JN*, Banko JL*, Hou L, Sonenberg N, Weeber EJ, Klann E, Nguyen PV (2007) ERK and mTOR signalling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent LTP. J Biol Chem 282: 27527- 35. PDF
Gelinas JN and Nguyen PV (2007) Neuromodulation of hippocampal synaptic plasticity, learning, and memory by noradrenaline. Central Nervous System Agents in Medicinal Chemistry 7:1-17. PDF
Gelinas JN and Nguyen PV (2005) b-adrenergic receptor activation facilitates induction of a protein synthesis-dependent late phase of long-term potentiation. J Neurosci 25:3294-3303. PDF